Early Diagnosis of Alzheimer’s Disease by a Synergistic Evaluation of Free Copper Ion in the Serum and SPECT Analysis

In this report, eight patients have been analyzed in order to demonstrate how a combination of two in vitro and in vivo assays might allow an early diagnosis of Alzheimer’s disease (AD). For all these subjects, the measurements of free copper ion in the serum by C4D test and brain perfusion by SPECT have been reported. The MRI did not evidence anomalies while a free copper value > 2.3 μM combined with a hypoperfusion in target areas led to the identification of AD.