DISTURBANCES OF SYNAPTOGENESIS IN THE CEREBELLUM OF OFFSPRING OF FEMALE RATS WITH CHOLESTASIS AND THEIR CORRECTION WITH URSODEOXYCHOLIC ACID

The purpose of the study was to evaluate the effect of mother's subhepatic cholestasis on the postnatal synaptogenesis in the cerebellum of offspring with the marker synaptophysin (SYN) as well as to assess the possibility of correction of the revealed disturbances with ursodeoxycholic acid (UDCA). 36 rat pups from 2 to 45 days old were studied. It was found that experimental cholestasis induced in the mother on the 17th day of gestation retarded synaptogenesis in the cerebellum of their offspring, especially in the early period after birth: in all cortex layers and nucleus interpositus of the cerebellum there were changes in the dynamics of the expression of the synaptic vesicles marker synaptophysin, while UDCA partially corrected these disturbances.