CORRELATION OF EXPRESSION OF HORMONE RECEPTORS AND HER2 WITH HISTOLOGICAL GRADING IN 60 CASES OF BREAST CARCINOMAS

Objective To analyse the expression of estrogen receptor, progesterone receptor and HER2 status using immuno histochemistry in 60 cases of breast carcinomas. To correlate the expression of hormone receptors and HER2 status with histological grading of tumor.Study design In this study, 60 cases of carcinoma breast were selected from department of pathology, Coimbatore medical college, Coimbatore for the period of September 2009 to July 2011. Immuno histochemistry for ER, PR and HER2 were performed. The results were analysed and the correlation of ER, PR and HER2 with histological grading was done.Results Out of 60 cases of carcinoma breast, hormone receptor expression was seen in 100 cases of grade1, 54.35 of grade 2 and 57.14 of grade 3. HER2 expression was seen in 0 cases of grade 1, 46.81 cases of grade 2 and 42.86 cases of grade 3.Correlation of hormone receptor expression with HER2 was also done. In grade 1 carcinoma hormone receptor expression was 100 and HER2 expression was 0. In grade 2 hormone receptor expression was 54.35 and HER2 expression was 46.81. In grade 3 hormone receptor expression was 57.14 and HER2 expression was 42.86Conclusion Hormone receptor status and HER2 testing are the two available modalities for effective management of patients with carcinoma of breast NOS type. Histological grading of breast carcinoma is also of paramount importance which should be included in the surgical pathology report. Therefore hormone testing and HER2 status are important ancillary investigations which should be performed in all cases of breast carcinomas.