THE CHEMOIMMUNOTHERAPY BASED ON DENDRITIC CELLS AND CISPLATIN IN EXPERIMENT

The aim of the study was to develop a scheme of combined chemoimmunotherapy and to investigate antitumor and immunomodulatory activity of chemoimmunotherapy regimen using the vaccine based on dendritic cells and low-doses of cisplatin in CBA mice with sarcoma-37. Maximal antitumor and immunomodulatory effects were observed after application of the vaccine based on dendritic cells in combination with doses of cisplatin concentration of 2 mg/kg. Among significant immunomodulatory effects of combination therapy it has to be noted the increased functional activity of natural immunity,in particular, enhancing of cytotoxic activity of natural killer cells and the ability of peritoneal macrophages, neutrophils and spleen macrophages to increase their absorbing activity and to produce the active oxygen forms. The obtained results prove the expediency of combining of chemo- and immunotherapeutic methods for the development of more effective approaches to prevent recurrence and metastasis after primary treatment of cancer patients.