Hypoxia induces therapeutic resistance and enhances subsequent reformulated tumorigenesis and metastasis

Dynamics of hypoxic environment generation within tumors are major pathogenic factors in the emergence of radio- and chemo-resistance of multiple diverse types of neoplasia. It is significant to consider various approach modalities in the treatment of tumors that are often significantly enhanced by hypoxia in further generating malignant transformation and progression. Focusing modalities implicate also repair mechanisms involved in correcting mutations such as insertions/deletions, translocations and base-damage. Such DNA repair pathways have direct impact on the outcome of radiotherapy and also chemotherapy that induce DNA lesions in therapeutically enhanced tumor cell death or apoptosis.