New Spectrophotometric Method for the Estimation of Naproxen in Tablets using N, N- di methyl urea as Hydrotropic AgentJournal: Current Research in Pharmaceutical Sciences (Vol.2, No. 3)
Publication Date: 2012-09-30
Authors : Mahendra Patel; Yashwardhan Saktawat; Rajesh K Nema; Rajesh K Maheshwari;
Page : 177-179
Keywords : ;
A novel, safe and sensitive method of spectrophotometric estimation in ultraviolet region has been developed using 7.5 M N, N- di methyl urea solution as hydrotropic agent for the quantitative determination of Naproxen, a poorly water-soluble drug in tablet dosage form. Naproxen shows maximum absorbance at 272 nm. Beer's law was obeyed in the concentration range of 10 to 60 μg/ml, N, N- di methyl urea does not absorb above 260 nm. Commonly used tablet excipients and N, N- di methyl urea did not interfere in spectrophotometric estimation. Results of the analysis were validated statistically and by recovery studies. Using 7.5 M N, N- di methyl urea solution for analysis of two different tablet formulations of Naproxen , the percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error.
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