EFFECT OF TWO AYURVEDIC DRUGS ON SERUM CALCIUM LEVEL IN OSTEOARTHRITIS INDUCED RATS AND OSTEOARTHRITIS PATIENTS

Background: To evaluate the comparative study of serum calcium level after treatment of cissusquadrangularis linn and zingiber officinale rocs in osteoarthritis induced rats and osteoarthritis patients. Method: Estimation of serum calcium levels are before and after treatment of tested drugs in osteoarthritis rats and patients 1. Animal treated: Cissus quadrangularis linn-450 mg/kg orally; Zingiber officinale rocs-450 mg/kg orally; cissus quadrangularis linn+ zingiber officinale rocs-450mg/kg orally; 2.Patients treated: Cissus quadrangularis linn-5 gm; Zingiber officinale rocs-5 gm and Cissusquadrangularis linn+ Zingiber officinale rosc-5 gm, all groups are twice a day orally with luke warm water. Results: Serum calcium levels are estimated before and after treatment of tested drugs in osteoarthritis rats and patients were: 1. Animal treated: Cissus quadrangularis linn (7.56 ± 0.35 to 9.06 ± 0.87) p<0.01; Zingiber officinale rosc was (7.82 ± 1.53 to 8.72 ± 0.68) p<0.05; cissus quadrangularis linn+ zingiber officinale rosc was (7.93 ± 0.73 to 9.72 ± 1.3) p>0.001; 2.Patients treated: Cissus quadrangularis linn (8.295±0.3069 to 8.81±0.27) p<0.0001.; Zingiber officinale rosc was (8.160±0.13 to 8.20 ±0.13) p<0.001;Cissusquadrangularis linn+ Zingiber officinale rosc was (7.86 ±0.36 to 8.705±0.2724) p<0.0001. Conclusion: Study evident that improvement in terms of increase in serum calcium was observed in animal as well as patients treated groups. The combination treatment of Cissusquadrangularis linn+ Zingiber officinale rosc showed extremely significant and increase of serum calcium level compared to standard drug of Dexamethasone in both tested groups Key words: Cissusquadrangularis Linn, Zingiberofficinale rocs, calcium, animals, patients