SPECTROPHOTOMETRIC DETERMINATION OF AMPRENAVIR IN FORMULATION SAMPLE

A validate rapid, economical and sensitive visible spectrophotometric method has been developed for quantitative determination of amprenavir in bulk drug and tablet samples.This method is validated for irinotecan with chromogenic reagent namely bromo cresol green (BCG) at λ max 417. The calibration curve was linear over a concentration range of 5-40 µg/ml. The relative standard deviation (R.S.D) is less than 1% and average recovery was above 99.60%. Efficient visible spectrophotometric detection at λmax 417nm enabled determination of the drug with no interference from tablet excipients. The proposed method is fast, sensitive, precise, accurate and efficient and can be used for analysis in quality control laboratories. Key Words: Ultraviolet-Visible Spectrophotometry, amprenavir, bromocresol green(BCG), Phosphate buffer, ion association complex.