NANOSUSPENSIONS - A PROMISING NOVEL DRUG DELIVERY SYSTEM

In the recent times there has been a tremendous increase in the novel drug delivery systems, hence nanotechnology i.e. use of Nano sized particles has been an emergent drug delivery system to meet the desired needs and efficacy of drug substances. Nano refers to particle size range of 1-1000nm. A nanosuspension can be defined as a very fine colloidal dispersion of drug particles in the aqueous vehicles with certain excipients as stabilizers, co-surfactants, organoleptic agents etc. Solubility is one of the major concerns in the modern drug discoveries hence the basic need for nanosuspension is to create a larger surface area of drug particles and to administer the drugs which are insoluble and increases the bioavailability. These can be administered by oral, parenteral, ocular and pulmonary routes. Nanosuspensions are a very promising strategy for hydrophobic drug substances. Various techniques of their preparation have been patented and applied. This review article describes about the methods of preparation, merits and demerits, application, and evaluation parameters. Keywords: Nanosuspensions, Homogenization, Media milling, Formulation, Evaluation