Invitro Characterization of Metformin Okra Alginate Microspheres: CRDDS

Metformin is an oral hypoglycemic agent which reduce the basal and post prandial plasma glucose without effecting insulin secretions, but it may cause freezing of arms & legs, muscles pain, stiffness &weakness due to its adverse effects it is recommended as a modified release dosage form. In this work ionically gelled modified alginate beads are prepared by using SA and plant derived natural polysaccharide (OKRA/Abelmoschus officinalis) blends with different concentration by using calcium chloride (CaCl2) as a cross -linker in an aqueous environment. In present work we prepared microspheres with different concentrations of OKRA mucilage and SA (sodium Alginate) was dropped into the 10 % Calcium chloride solution and prepared alginate spheres were evaluated for micrometric properties i.e. Bulk density, C.I, angle of repose and characterized by SEM, swelling Index, %yield, Drug entrapment