One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivativesJournal: Asian Journal of Green Chemistry (Vol.2, No. 4)
Publication Date: 2018-07-16
Authors : Ramin Javahershenas; Jabbar Khalafy;
Page : 318-329
Keywords : ;
A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.
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Last modified: 2018-07-17 04:16:23