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Kabachnik-Filds Reactions with 2,3-Trimethylene-1,2,3,4-Tetrahydropyrido[2,3-D]Pyrimidin-4-One

Journal: International Journal of Mechanical and Production Engineering Research and Development (IJMPERD ) (Vol.10, No. 3)

Publication Date:

Authors : ; ;

Page : 12031-12038

Keywords : 2; 3-trimethylene-3; 4-dihydropyrido[2; 3-d]pyrimidin-4-one; 2; 3-trimethylene-1; 2; 3; 4-tetrahydropyrido[2; 3-d]pyrimidin-4-one; 2-Aminonicotin acid; pyrrolidone-2; Kabachnik–Filds reactions & IR spectra;

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In the article synthesized 2,3-trimethylene-3,4-dihydropyrido[2,3-d]pyrimidin-4-one from 2-Aminonicotinic acid and pyrrolidone-2 in the presence different agents, such as PCl5, POCl3. Its reduction reaction with NaBH4 carrying out. Obtained 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-one – this three-component coupling of a carbonyl, an amine and a hydrophosphoryl compoud leads to α-aminophosphonates, phosphorous acid-formaldehyde; aldehydes in three component system; aminomethylphosphonic acid synthesis based on kabachnik-filds reaction. 2,3-trimethylene-3,4-dihydropyrido[2,3-d]pyrimidin-4-one 35% da product obtained. The reason of low reaction yield was studied. Structures were confirmed using IR and 1H NMR spectroscopies. Obtained product reduced using NaBH4 and 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-one synthesis was carried out with high yield. 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-one and respective aminophosphonic acids were synthesized in three component system with high yield.

Last modified: 2020-10-03 16:25:04