The Study of Hepatoprotective Action of the Drug used for the Treatment of Toxic Hepatitis in Piglets

Nowadays, there is a large number of ways to prevent and treat toxic hepatitis. Taking into account the fact that tissue hypoxia plays a significant role in the pathogenesis of hepatocyte damage leading to disruption of mitochondrial functions, depletion of ATP reserves with the activation of free radical processes, the use of drugs containing mitochondrial substrates such as succinic acid (succinate) is effective to have an additional influence on the course of ischemic processes in the hepatocyte, moreover, it has been proved that succinic acid and its derivatives have an antioxidant action. The aim of the research was to determine etiological factors, to study the effectiveness of the new drug that contains succinic acid and organic phosphorus compound and its effect on the clinical and physiological status, some hematological factors, as well as the productivity of piglets with toxic hepatitis. It has been found that the etiological factors that cause toxic hepatitis in the weaned piglets on the experimental farm are exogenous intoxication, lack of selenium, methionine and Vitamin E in feeds. The administration of the studied drug at doses of 0.3 and 0.5 ml/kg intramuscularly three times a day in addition to the adopted scheme of treatment had a stimulating effect on haematopoiesis of the piglets - at the end of the experiment, the levels of hemoglobin and erythrocytes increased compared to the control group, protein and carbohydrates metabolism in piglets improved, the function of the liver recovered. There was also a stimulating effect on the productivity and liveability of the piglets, but a more pronounced effect was achieved in the piglets treated by the studied drug at a dose of 0.5 ml/kg of live weight.