Topological Optimization of Hollow Fiber Membranes to Enhance Hemodialyzer Efficiency

Amongst the most common issues in kidney disease is atypical decline of fluid elimination in the body, which raises acid levels and increases the healthy range of molecules such as uremic toxins, glucose, creatinine, β2 - micro globulin. Variables that characterize the dialyzer framework are very vital because they determine the overall Uremic toxin solute molecules clearance. Such contaminants can be eliminated by manufacturing membrane frameworks which are efficient, due to the wide availability of technologies in production of membranes and hollow fibers which can vastly improve dialyzer efficiency. Since system criteria and architecture of dialyzer determine the level of removal and also the hold of beneficial molecules in the blood, the layout of processing and designing hollow fibers is of paramount importance. In this paper, a study is performed on tweaking the geometrical parameters of hollow fibers namely inner diameter, length of fiber and their effects on solute (Uremic toxins) clearance. To validate this model simulations are performed on Matlab, Simulink and COMSOL software. The study also discusses about the limitations in designing hollow fibers for hemodialyzer and finding the trade-off values for optimal geometrical parameters that increase dialyzer productivity