REVIEW: Increased Dissolution Rate Ofloxacin in Solid Dispersion Systems

Ofloxacin (OFX) is a broad-spectrum fluoroquinolone group antimicrobial, including the second-generation fluoroquinolone class of antibiotics, which is very effective against gram-positive and gram-negative bacteria. This compound has a low level of solubility in the small intestine's pH conditions, so it requires increased solubility and dissolution with a solid dispersion system. Several methods and chemical additives have been used to improve the dissolution rate of Ofloxacin. This review article analyzed literature studies on the increase in dissolution rate of Ofloxacin in a solid dispersion system. We carried out the literature review through a search with Google Scholar. The analysis showed that from several methods, it was found that the ternary system with surfactant enhancer in the form of Sodium Laurier Sulfate and other surfactants could increase the dissolution rate of Ofloxacin.