Evaluation of Analgesic Activity of Kadukkai Podi (Terminelachebula Retz) in Animal Models

In recent years, there has been an increasing interest to find new anti-inflammatory and analgesic drugs with mild side effects from natural sources and siddha formulations.The analgesic effects were evaluated for siddha Single herb Kadukkai Podi in rat using acetic-acid writhing test and hot plate methods.Analgesic activity is found using Acetic acid-induced writhing test in adult male albino mice (25-35 g). The Kadukkai Podi demonstrated a dose-dependent, significant antinociceptive activity in animal models of pain. The analgesic activity shown in models of pain is indicative that siddha single Herb- Kadukkai Podi200mg/kg showed centrally and peripherally mediated antinociceptive properties. The concluded that possesses anti-nociceptive properties which are probably mediated via inhibition of prostaglandin synthesis as well as central inhibitory mechanisms which may be of potential benefit for the management of pain and inflammatory disorders.