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Psycho-emotional state of rats under thyroid dysfunction

Journal: Medicni perspektivi (Vol.19, No. 1)

Publication Date:

Authors : ;

Page : 10-15

Keywords : psycho-emotional state; experimental hyper- and hypothyroidism; spontaneous behavioral activity; anxiety; anxiolytic effect; gamma-aminobutyric acid (GABA);

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Spontaneous behavioral activity of white rats and concentration of glutamate, glycine and gamma-aminobutyric acid in the neocortex in experimental hyper- and hypothyroidism was investigated. It was found that an excess of thyroid hormones was accompanied by emotional and anxiolytic effects in terms of reducing duration of grooming by 37% and increasing number of transitions and the time spent in the illuminated cross-shaped maze arms (26 % and 35%). Such behavior changes occurred against a background of increasing concentrations of GABA by 52 % (p<0,05) in the cortex of animals with experimental hyperthyroidism. Perhaps, the psycho-emotional state of the organism is modulated by thyroid hormones through the GABA - ergic system of neocortex.

Last modified: 2014-12-15 21:50:17