MPV as Prognostic Factor for Patients with Coronary Artery Diseases in Sudan

Background: The main cause of Coronary Artery Disease (CAD) is a complication of atherosclerosis due to blockage of blood flow in the arteries of the heart. It has been observed that platelet activation and aggregation are critical processes in initiation of atherosclerotic lesions and formation of thrombosis inside coronary arteries. Objective: The aim of this study was to evaluate the platelet indices among patients with acute coronary syndrome (ACS). Method: A clinical based (Alshaab Hospital in Khartoum), case- control study was conducted on 50 patients known as confirmed cases with acute coronary artery disease and 50 cases designated as healthy controls. On each blood sample drawn from each case (patients and control), the following platelet indices were measured using Mindary BC 3000: Platelets count, Mean platelets volume (MPV), platelets distribution width (PDW) and platelets Crit (PCT). Results: A statically significant difference in mean values of the measured platelet indices was found in the values of MPV only, that significantly raised in patients with ACS compared to controls (9.18 ± 0.99) vs (7.59 ± 0.71) respectively, (p value ˂ 0.001). The result showed the increased mean values PDW and PCT were statistical insignificance, (p value (0.82) and (0.18) respectively. Furthermore, there was insignificant decrease in platelet count among patients when compared to control, p value (0.205). Conclusions: In light of current results of this study, MPV could be used as a predictor for early detection of thrombosis in patients with ACS, These findings would encourage routine request of MPV as prognostic marker for early detection of coronary event.