Lactobacillus reuteri DSM 17938 Increased the Fibroblast Count in the Wound Healing Process on Diabetic Wistar Rats

Scope: This study aims to see the Lactobacillus reuteri DSM 17938 effect on diabetic Wistar rats' wound healing process. Method and Results: The randomized post-test only control group was applied in 28 male diabeticWistar rats aged 3-4 months. The subjectswere dividedinto four groups; two study groups with5 and 12 days intervention durationand two control groups. The study groups were given glimepiride and Lactobacillus reuteri DSM 17938; the control groups were given glimepiride and placebo. All interventions were given for 30 days before wounded using a punch biopsy and given for 5 and 12 days after. Histopathological examination was performed to assess neovascularization, fibroblast count, and epithelialization. On day 5, the study found that the mean fibroblasts count in the study group was higher than the control. However, there were no significant differences in neovascularization, the epithelial thickness andgap between the study and control groups. On day 12, similar results were found, although there wasan improvement in all variables. Conclusions: Lactobacillus reuteri DSM 17938 increased the fibroblasts counts on day five but did not improve neovascularization and re-epithelialization in diabeticmale Wistar rats; nevertheless, the probiotic showed a potential positive effect.