In-vitro Anticoagulant and Antiplatelet Activity of Artemisia herba-alba AssoextractJournal: International Journal of Science and Research (IJSR) (Vol.9, No. 12)
Publication Date: 2020-12-05
Authors : Dr Osama M Alshehri;
Page : 1369-1373
Keywords : DVT; Deep Vein Thrombosis; PT; Prothrombin time; CR; Clot Retraction;
Background: Cardiovascular diseases involving deep vein thrombosis (DVT), strokes, and heart attacks are the main causes of morbidity and mortality in countries throughout the world. In recent years, many people have begun to use traditional (alternative) medicine in the treatment of the majority of diseases because it is natural, cheap, and safe with minimal or no side effects when compared to chemical substances. Objective: The present study aimed to determine the in vitro anticoagulant and antiplatelet activity of the Artemisia herba-albaAsso extract. Method: The blood samples used in the evaluation of the anticoagulant and antiplatelet activity of the plant extract in this study were taken from healthy volunteers. Prothrombin time (PT) and clot retraction (CR) tests were performed before the addition of A. herba-albaAssoextract (as controls) and after the addition of the extract at different concentrations (2 %, 4 %, and 8 %) as the test group. The results were analyzed statistically using SPSS. Results: A significant increase in the means of the PT and CR tests was revealed upon incubation of the A. herba-albaAssoextract with normal blood samples (pless than 0.05) for all concentrations in both the PT and clot retraction tests. Conclusion: This study has demonstrated that the A. herba-albaAsso extract has strong anticoagulant and antiplatelet activity, so it may be used for the management of thrombotic diseases.
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