The Effect of Vitamins B on Myelination of Injured Peripheral Nerve in Rat

Introduction Neuropathy is one of the common neurological problem which is cause by many factors, one of these factors is trauma. Traumatic neuropathy affects myelin sheath with or without nerve fiber. Demyelination includes disintegration of myelin sheath and myelin nucleus. Many medications have been used to treat traumatic neuropathy. One of these medications is vitamin B. Aim of the study Effect of vitamins B on myelination of degenerative traumatic neuropathy. Material and Method Forty albino rats were used in this study. All the animals exposed to crush injury of the sciatic nerve. These experimental animals were divided into 4 groups. Three of them received one type of vitamins B including vitamin B1, B6, B12 besides, the forth group received placebo. After 6weeks of experiments, crushed area of sciatic nerve was studies histologically and immunohistochemically. Result The group of animals, Which exposed to crush injury of sciatic nerve and treated with vitamin B12 revealed best regenerative process more than that which received B1 which in turn elicited better result than that group received vitamin B6. Discussion Vitamin B12 has a positive effects on myelination of nerve fiber, therefore it processed better regenerative reaction than that treated with vitamins B1 and B6.