Role of C-Reactive Protein in Development of Hypertension

Hypertension is one of the most important risk factor for cardiovascular disease and has become an increasingly important contributor to the global health burden. Inflammation and mounting of inflammatory markers (acute phase reactants) are important pathogenic mechanism in development of hypertension. It could be either a causative factor in the pathogenesis of hypertension or a sequel to it. In the view of the probable involvement of the acute phase reactants, present study was planned to investigate role of C-reactive protein (CRP) in development of hypertension and find out its correlation with blood pressure if any exist. The study was done at MBS hospital & New Medical College & Hospital, Kota. CRP levels in the serum of 50 hyper-tensive cases and 50 healthy sex and age matched control subjects were analysed on Biochemistry Fully auto-analyzer EM-360 by TRANSASIA using standard protocols. Data were analyzed with the help of Microsoft excel 2007, using student's t-test, and strength of association between two variables is measured by Pearson's correlation coefficient (r). CRP level showed a significant positive correlation with systolic blood pressure (pless than0.001). So appropriate measures should be taken to bring these parameters in limit for better prognosis and to avoid ill effects of hypertension.