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Synthesis, Characterization and Biological Evaluation of N2, N4-dip-tolylquinazoline-2,4- Diamine and N2, N4-bis(4-chlorophenyl) quinazoline2,4diamineQuinazoline Derivatives

Journal: International Journal of Scientific Engineering and Research (IJSER) (Vol.5, No. 7)

Publication Date:

Authors : ; ;

Page : 412-416

Keywords : Quinazoline derivative; Antifungal activity; N2; N4-di p-tolylquinazoline-24- diamine; N2; N4-bis(4-chlorophenyl)quinazoline-24-diamine; Quinazolin-24-diol; 24-dichloroquinazoline;

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ABSTRACT:Present work includes synthesis of N2, N4-di p-tolylquinazoline-2, 4- diamine and N2, N4-bis(4-chlorophenyl)quinazoline-2, 4-diamine which are quinazoline derivatives and out of these two N2, N4-bis(4-chlorophenyl)quinazoline-2, 4-diamine (IV) have shown ?antifungal activity? against Aspergillusflavus. At first 2- amino benzoic acid react with urea attemperature 130 ?C to 140?C to gives Quinazoli-2, 4-diol (I) which on further reaction with POCl3 at 150 ?C for 24 hr. to gives second product 2, 4-dichloroquinazoline (II). Then 2-4-dichloroquinazoline (II) react with p-toluidine to gives N2, N4-di p-tolylquinazoline-2, 4- diamine (III)and again this 2, 4-dichloroquinazoline (II) react with p-chloroanline to gives N2, N4-bis(4-chlorophenyl)quinazoline-2, 4-diamine (IV) which characterized by I. R., 1HNMR and 13CNMR.

Last modified: 2021-07-08 16:10:09