The Degradation Pathway of 4-Chlorobenzoic Acid by Genetically Modified Strain of Pseudomonas aeruginosaJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 11)
Publication Date: 2021-11-05
Authors : Ashok Kr. Singh;
Page : 663-667
Keywords : 4-chlorobenzoic; Pseudomonas aeruginosa; 4-chlorocatechol; catechol; cis; cis-muconic acid;
Pseudomonas aeruginosa a genetically modified strain degrading 4-chlorobenzoic acid was isolated from soil. This bacterium could degrade 15 mM of 4-chlorobenzoic acid rapidly with stoichiometric formation of chloride ion. The metabolites such as catechol and cis, cis-muconic acid was detected in the grown medium. Further, ring cleavage enzyme catechol 1, 2-dioxygenase was detected and isolated in crude cell extract. Thus, the biodegradation pathway of 4-chlorobenzoic acid by this bacterium was proposed involve the catechol as intermediate compound and further this converted into cis, cis-muconic acid by the process ortho ring cleavage pathway.
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