A Study on Effect of Food on Pharmacokinetics of Clindamycin: A ResearchJournal: International Journal of Science and Research (IJSR) (Vol.11, No. 4)
Publication Date: 2022-04-05
Authors : Akshay S. Kshirsagar; Vipul M. Patil; Sachinkumar Patil;
Page : 304-307
Keywords : Clindamycin; Bioavailability; metabolism; pharmacokinetics;
Clindamycin formulations (capsules, administered orally were studied in twenty adult indian human males) in fed and fasting conditions. Bioavailability, pharmacokinetics and recovery were determined for each subject. A standard dose 150mg was used in study. The mean pharmacokinetics parameters calculated for each subject my SAS software (Version 9.4). In pharmacokinetics parameters we calculated Cmax and AUC(0-t). These mean values are lower than those reported in the literature for healthy volunteers, and the variation between patients is also larger. The blood concentration-time curves for the tablets were very scattered, which was far less the case for the capsules. The maximum blood concentration (Cmax) for fed study were very low than the fasting study. The time at Cmax were more for fed condition as compare to fasting condition. The mean absorption rates found for the two study did differ from those found in healthy volunteers, clindamycin being absorbed significantly more slowly in fed condition than fasting condition.
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