A Comparative Study of Homocysteine, Cyanocobalamine, Folate, Lipid Profile and Serum Creatinine Level in Hypothyroid Subjects before and During Treatment

Introduction: Hyperhomocystenemia is a disease involving abnormal homocysteine metabolism and is characterized by increased level of total homocysteine concentration (normal 5-15 ?mol/L). Many factors like dietary folate, cyanocobalamine deficiency or thyroid disorder are the most common causes for increased homocysteine level. This present study was planned to delineate the usefulness of levothyroxin, supplementation of folate and cyanocobalamine in patients of hypothyroidism to evaluate change in homocysteine level before and during treatment. Also to find out correlation between levothyroxin, cyanocobalamine and folate with homocysteine. Material and Method: The present study was conducted on 75 pateints of hypothyroidism of either sex in department of biochemistry, J.L.N. medical college and hospitals, Ajmer. Serum homocysteine, cyanocobalamine, folate level was measured by ELISA while thyroid function test were evaluated by RIA method. Result and discussion: There was highly significant change in homocysteine, cyanocobalamine, folate, total cholesterol, HDL, VLDL and LDL in hypothyroid subjects before and during treatment (Pless than0.0001). This emerging evidence suggest that these parameters are influenced by levothyroxine used in treatment of hypothyroid disorder and usefulness of supplementation of cyanocobalamine and folate for significant improvement of serum lipid profile. Conclusion: It is concluded that supplementation of levothyroxin, cyanocobalamine and folate in hypothyroid patients can cause significant decrease in level of homocysteine and significant improvement of serum lipid profile, which decreases risk of coronary heart disease in hypothyroid patients.