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Journal: Journal of the Grodno State Medical University (Vol.20, No. 2)

Publication Date:

Authors : ; ; ; ; ; ;

Page : 187-196

Keywords : hypertension; atrial fibrillation; uric acid; hyperuricemia; xanthine oxidase;

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Background. Cardiovascular diseases predominate in overall morbidity, disability and mortality of the population both in Belarus and in many other countries. The study of additional risk factors for the development of cardiovascular diseases including hyperuricemia is of undoubted interest. A rise in serum uric acid level is increasingly associated not only with the possible risk of such a classic disease as gout, but also with such pathological processes as hypertension and atrial fibrillation. The aim of the study is to study purine metabolism and the frequency of hyperuricemia in patients with hypertension and atrial fibrillation. Material and methods. The study results of products of purine metabolism in 104 patients with hypertension and/or atrial fibrillation under the age of 65 are presented. The serum uric acid level was determined by an enzymatic colorimetric method. The activity of the xanthine oxidase enzyme was measured via solid phase “sandwich” method using ELISA Kit Cat. for enzyme immunoassay. Xanthine, hypoxanthine, adenosine, inosine was measured by a highperformance liquid chromatography. Results. High serum uric acid level was revealed in 22.1% of 154 patients in the study. The patients with persistent and permanent atrial fibrillation had higher uricemia than the ones with paroxysmal atrial fibrillation. The patients with hyperuricemia were more likely to have permanent (33.3%) and persistent (39.4%) atrial fibrillation. Xanthine oxidase activity in 54% of subjects with hypertension and atrial fibrillation exceeded normal values. A significant correlation was found between elevated uric acid levels and left atrial dilatation (U=1616.0, p=0.002, rrb=-0.379). Hyperuricemia may be associated with the value of the left ventricular ejection fraction in patients with hypertension and atrial fibrillation (U=831.0, p=0.017, rrb=0.291). Conclusion: Hyperuricemia occurs in 22.1% of patients with hypertension and atrial fibrillation and is associated with cardiac remodeling.

Last modified: 2022-05-26 22:30:59