THE SORBENTS APPLICATION FOR TREATMENT OF NEUROISCHEMIC DIABETIC FOOT ULCER

To investigate the clinical efficacy of the treatment of patients with neuroishemic diabetic foot ulcers (DF) by using nano-dispersed antimicrobial compositions based on silica sorbents. We observed 78 patients, 27 male (35%) and 51 female (65%). Diagnosis of DF was carried out in accordance with the International Consensus on the Diabetic Foot. Status of the main blood flow in the lower limbs were assessed in terms of ankle-brachial index. Patients received a complex treatment protocols in accordance with Ministry of Health Ukraine. Prescribed broad-spectrum antibiotics, derivatives of thioctic acid, neurotropic vitamin preparations, antiplatelet effects. Compensation of diabetes carried out by insulin. Patients were divided into 2 groups, the treatment group without the use of applicative sorption and group using applications on the sorption-ulcer antibacterial nanocomposite. Treatment is considered effective when complete epithelialization ulcers. Statistical processing of the results of research carried out by methods of parametric statistics. The results of the study on the use of treatment of necrotic ulcers in patients with diabetic foot show declines in terms of ulcer healing in patients treated with applications of sorptionantibacterial nanocomposite. Full-epithelialization of ulcers is achieved by an average of 10 days faster than treatments ulcers without applicative sorption. The duration of treatment for patients with neuroischemic diabetic foot ulcer increases after 70 years in male and female. The use of antimicrobial compositions based on nanosized silica shortens complete epithelialization of ulcers an average of 10 days compared with the treatment of patients with no applicative sorption