Evidence of pathogenic mechanism that cause diabetes and therapeutic implications

Backgound: The aim of this paper is to review the cellular process that potentially link diabetes. Diabetes Mellitus is a metabolic disorder characterized by hyperglycemia due to defect in insulin secretion, insulin action or both. Methods: The major cause of death and illness is due to the complications caused by increased glucose concentrations. All the accessible antidiabetic drugs are associated with side effects. Results: The combination therapy could be a novel and highly effective healing strategy to manage hyperglycemia. Combination of viable drugs with phytochemicals may reduce the side effects caused by these synthetic drugs. Conclusion: Herbal products have been thought to be inherently safe, because of their natural origin and traditional use rather than based on systemic studies.