SYNTHESIS, CHARACTERIZATION AND ANTI BACTERIAL ACTIVITY OF NOVEL 2-MERCAPTOBENZOXAZOLE DERIVATIVES

Benzoxazole and its derivatives are important class of bioactive molecules, their importance is due to their versatile application in the field of drugs and pharmaceuticals as well as in chemical systems. It finds use in research as a starting material for the synthesis of larger, usually bioactive structures. A new series of Benzoxazol-2-ylthio-N ’ -(4- substituted) acetohydrazide derivatives (IV a-k), were obtained by synthesising new schiff’s bases derived from benzoxolyl-2-mercaptoacetohydrazide derivatives by treating with various aryl/hetero aryl aldehydes. Their chemical structures have been confirmed by 1H-NMR, 13C-NMR, FT-IR and Mass spectral data. The synthesised derivatives (IV a-k) were screened for their in-vitro anti bacterial activities by agar diffusion method. Among the synthesized derivatives IVb, IVe, IVk, IVi showed significant antibacterial activity. Key Words: Benzoxazole, heterocyclic compounds, aryl/hetero aryl aldehydes, schiff’s bases, anti bacterial activity.