Experimental substantation of multimodal analgesia for hyperalgesia treatment

An inadequate analgesia in the early postoperative period impairs the flow and the forecast of this period in children and increases the level of postoperative complications and contribute the development of hyperalgesia. Methods. The study was used 50 nonlinear mice which weigh 20-25 g. Antiflogogenic effect of drugs was studied on the model of carageenin edema in white nonlinear mice which weigh 20-25 g. The carageenin edema was used as model of hyperalgesia. The carageenin edema was modeled by sublantar injection of the 0,05 ml 1% carageen in solution in the right hind limb of the animal. Results. Combined use of paracetamol and bupivacaine, as well as monotherapy with this drugs, showed moderately expressed antiflogogenic effect (AFE amounted to 25,3, 20,9 and 11,6% respectively), while injection of fentanyl was conversely accompanied by increase of the prostaglandin edema. The conduction anesthesia with bupivacaine along with paracetamol lead to more expressed analgesic effect, which was confirmed by cortisol level. In 5th group (paracetamol with bupivacaine) cortisol level was 102,8 ± 8,1 ng/ml, which 2,5 times lower than in the 2nd (fentanyl) and 1,64 times less than in the 3rd one (paracetamol) (р<0,05). Conlusion. The comprehensive study of the pain behavior reactions, physiological indicators, and laboratory stress tests showed that using of conduction anesthesia with bupivacaine combined with non-opioid analgesic paracetamol lead to more expressive analgesiceffect.