ANTICANCER EFFICACY OF CYCLEA PELTATA ON HUMAN BREAST CARCINOMA CELLS

Cancer has now been designated as a preventable disease with the increasing interest by the research community. The impartial administration of chemical treatments has now shifted to natural products due to the side effects observed with chemotherapy. In the present study, a pharmaceutical approach is undertaken to screen the anticancer potential of Cyclea peltata against breast cancer. We examined the in vitro anticancer potential of MCF-7 cancer cell lines by MTT assay using various concentrations of the methanol extract of the plant. In silico analysis were carried out by Schrodinger suite. We found that the active compounds present in the extract effectively inhibit the proliferation of cancer cells in dose dependent manner. Molecular docking analysis showed that the active compounds in the methanol extract are best for increasing the expression of tumor suppressor protein and thereby inhibit the cell proliferation. It can be conclud that the active compounds from the plant extract can act as better drug candidates for anticancer activity