BIOCHEMICAL MARKERS FOR THE EVALUATION OF BONE TISSUE REMODELING IN OSTEOPENIA AND OSTEOPOROSIS

The literature data on the changes in the level of specific biomarkers used for evaluating the processes of bone resorption and remodeling in osteopenia and osteoporosis have been analyzed. The determination of the concentration of osteocalcin, the C-terminal propeptide of procollagen type I and the N-terminal propeptide of procollagen type I is most informative for evaluation of bone tissue formation. The determination of the concentration of the C-terminal telopeptide of type I collagen and the activity of plasma tartrate-resistant acid phosphatase, the evaluation of the urinary concentration of deoxypyridinoline are most useful for assessment of bone resorption. Biochemical markers of bone tissue metabolism are quite dynamic, which allows us to assess in a timely manner the balance between the formation of bone tissue and the processes of resorption during treatment for evaluating its effectiveness.