SOME NEW 1,3,4-OXADIAZOLES AS ANTIMICROBIAL AGENTS

Some new 5-[(((α-phenyl/methyl)benzylidene)amino)oxy]methyl/ethyl-2-amino/4-substituted aryl/ aryloxymethylarmercapto/piperidino/ morpholino-1,3,4-oxadiazoles (2a-d–5a-d) with biologically active biostere methyelne amino oxy methyl/ethyl moiety, were prepared starting from α/β-[((α-(phenyl/methyl) benzylidene)amino)oxy acetic/propionic acid hydrazides (1a-d). The structures of the compounds have been characterised by elemental and spectral (IR, 1HNMR and mass) analysis. All the newly synthesised compounds have been screened for their antimicrobial activity by cup plate method, against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Rhizoctonia bataticola. Some of the newly synthesised compounds have been evaluated for antituberculosis activity against, Mycobacterium tuberculosis H37Rv strain as well by BACTEC radiometric system at Southern Research Institute and Frederick Research Centre, Frederick, MD.