THE EFFECT OF ANTIOXIDANT VITAMIN OF THE DRUG ON THE METABOLISM OF BONE TISSUE IN CHRONIC CHEMICAL EXPOSURE IN THE EXPERIMENT

Daily chronic intoxication by chlorine-organic compound (dichloromethane) to a total dose of 0,1 LD50 of Mature white rats causes intensification of processes of free radical oxidation, a decrease in the activity of antioxidant enzymes and increase in the content of free hydroxyproline in homogenates of the epiphyses of tubular bones. In the blood plasma of experimental animals increases the level of C-telopeptide collagen type I at a constant activity of bone alkaline phosphatase. In the introduction, experimental animals antioxidant vitamin preparation «Triovit» for three weeks at a dose of 50 mg/kg per day on the background of intoxication with dichloroethane were determined in blood and homogenates of the epiphyses of tubular bones (femur) of animals, the condition of oxidant-antioxidant system in blood plasma – the substance of markers of bone remodeling in bone tissue homogenates was determined by the content of free, belkovosvazavatei hydroxyproline and glycosaminoglycans. Introduction vitamin antioxidant drug in animals contributed to the increase of the antioxidant resources of bone tissue, prevented the development of oxidative stress. Triovit had a beneficial effect on bone metabolism, in the blood plasma decreased level of C-terminal telopeptides, the inhibition of resorptive processes in the bone tissue during intoxication with chlororganic compounds in the blood plasma, a decrease in the content of parathyroid hormone and increase in the content of total calcium, magnesium and phosphorus, indicating a normalization of calcium-phosphorus metabolism. The effectiveness of the introduction trivita affected the decrease in resorptive processes in the bone tissue during intoxication with dichloroethane and in the study of the metabolism of the main protein collagen.