Polycystic Ovary Syndrome and Metformin

Polycystic Ovary Syndrome (PCOS) is the common endocrinological disorder of women in reproductive ages. It is generally accepted that insulin resistance plays a significant role in PCOS pathogenesis. Metformin is the most commonly studied insulin sensitizing drug in treatment of PCOS. The use of metformin may have a favorable effect in some subset of the population of women with PCOS. The aim of this review was to evaluate the uses of metformin in PCOS related infertility, pregnancy loss, hyperandrogenism, endometrial and cardiovascular abnormalities.