EFFICIENCY OF IMMUNOMODULATORY THERAPY AT CHRONIC PYELONEPHRITIS AT CHILDREN

The research objective is studying the effect of immunomodulatory therapy on clinical scores and the state of immunologic reactivity in children with chronic pyelonephritis. Material and methods. The study included 130 children aged 8–12 with a relapsing course of chronic pyelonephritis (CP). The first group of patients with CP (43 patients) received a complex conventional therapy, the second group of patients with CP (30 patients) received complex treatment in combination with polyoxidonium injections, the third group of patients with CP (30 patients) received complex treatment in combination with courses of Imunofan injections. We studied clinical score of patients, investigated the content of populations and subpopulations of lymphocytes in the blood, immunoglobulins and circulating immune complexes in the blood serum, phagocytosis, cytokine content in serum blood in the active stage of the disease, in the stages of partial and complete clinical and laboratory remission. Results. In the first group of patients with CP, who received complex conventional therapy, the complete, but short-term clinical and laboratory remission occurred, during which changes in many parameters of immunologic reactivity remained. In the second and third group of patients with CP, who received complex treatment in combination with injections of polyoxidonium and Imunofan, the onset of prolonged complete clinical and laboratory remission was observed, during which normalization of indicators of immunologic reactivity was observed.