STRESS-LIMITING MECHANISMS OF ADAPTA-TION TO IMMOBILIZATION STRESS IN HIGH-RESISTANT AND LOW-RESISTANT TO HYPOXIC HYPOXIA FEMALE AND MALE RATS

The basis of the development of many diseases is hypoxia, in particular the cardiovascular system. The sedentary lifestyle also leads to the development of diseases of the cardiovascular system. In order to ensure adequate adaptation to harmful environmental factors, activation of stress-limiting systems is required. These include antioxidant and cholinergic systems. The aim of the research is to determine param-eters of the antioxidant system and condition of the au-tonomous nervous system in rats of different gender with a low-resistance to hypoxia with immobilization stress. Material and methods.Immobilizationstress was modelled 4 times by an hour-long immobilization of rats the back down with an interval each 24 hours. In the heart, the activity of superoxide dismutase (SOD), cata-lase, the concentration of reduced glutathione, activity of glutathione peroxidase (GP), glutathione reductase (GR), and peroxidase activity in blood were determined. Ani-mals underwent cardiointervalography. Results. In intact male rats, compared with fe-males, there was higher activity of SOD, catalase, PAC, GH, and less - GP. Immobilization of females leads to activation of SOD, catalase, GH and reduction of gluta-thione system, PAK. In males, they remain at the level of control values of SOD, catalase, reduced glutathione, reduced PAC, GP, GR. In intact males, sympathetic car-diovascular effects, in particular adrenaline excretion, prevail. Immobilization leads to decrease of adrenergic effects in males and their increase in females. Conclusions. In intact low-resistance to hypoxia male rats, compared with females, higher antioxidant activity. Immobilization leads to activation of superoxide dismutase, catalase, glutathione reductase and decrease in the glutathione system, blood peroxidase. In males, the levels of superoxide dismutase, catalase, reduced gluta-thione, blood peroxidase, glutathione peroxidase, and glutathione reductase remain at the control level. In intact males adrenergic effects on the heart prevail. Immobiliza-tion of rats leads to decrease tone of the sympathetic portion of the autonomic nervous system, which has an oxygen-retaining effect and its increase in females.