STATE OF THE BLOOD OXYGEN TRANSPORT FUNCTION IN OBSTRUCTIVE SLEEP APNEA/HYPOPNEA SYNDROME

Summary. Оbstructive sleep apnea / hypopnea syndrome (OSAHS) is a topical medical problem and can lead to important medical consequences. OSAHS-associated biological changes are caused by periodic hypoxia and intermittent hypercapnia. The state and clinical signifcance of the oxygen transport function in OSAHS have not been studied and this was the purpose of the present research. The obtained results indicated the development of compensated metabolic acidosis during OSAHS: an increase in the lactate level with pH being within normal limits. There was a decrease in hemoglobin-oxygen affnity (a shift of oxyhemoglobin dissociation curve rightwards), regulating processes of tissues oxygenation during hypoxia. There also was a positive compensatory reaction in OSAHS. The identifed changes correlated with the severity of sleep apnea.