APPLICATION OF CELLULOSE DERIVATIVES IN EXPERIMENTAL SURGERY OF PARENCHYMAL ORGANS

The most important problem of modern surgery is providing a reliable hemostasis in surgical interventions and minimum blood loss in injury of internal organs and also development and introduction of effective blood-saving technologies into practical healthcare. One of the main tasks of abdominal surgery of parenchymal organs is search for new effective hemostatic means, such as hemostatic sutures, that can replace traditional methods. To provide local hemostasis, surgeons use various methods, one of them being application spongy means. However, these materials do not completely meet the requirements of practicing surgeons. Therefore, at present an actual problem is development and improvement of medical products made of different biodegrading polymers, which will permit to expand potentials of surgery in treatment of «complex» patients and to achieve positive results in surgery of parenchymal organs. In this work the structure and properties of such polymer as carboxymethylcellulose and its sodium salt are analyzed, since these substances are promising chemical compounds for manufacture of hemostatic application spongy implants, which is confirmed by a number of the published works. Besides, in the article, the history of production, the state of industrial production of sodium carboxymethylcellulose and classification of local hemostatic means are given, mechanisms of hemostatic effect of cellulose derivatives such as oxidized cellulose, sodium salt of carboxy-methylcellulose, are considered.