The Organometric Characteristics of the Thyroid Gland of Reproductive Age Rats Exposed to Moderate Chronic Hyperthermia in Combination with Inosine

The purpose of the study was to examine organometric characteristics of the thyroid gland of reproductive age rats when they are affected by chronic hyperthermia of moderate degree in combination with the use of inosine. Material and methods. The experiment was carried out on 60 white linear male rats with an initial mass of 180-230 g (aged 10-12 weeks). The animals of this series were divided into groups, depending on the agents acting on them. The first group consisted of control rats, which were also in the chamber for 5 hours at a temperature of 21°C. The second group included animals subjected to chronic hyperthermia of moderate severity (42.0-43.1°C) with concomitant administration of inosine. Hyperthermia was simulated from 8 am to 1 pm (5 hours daily) for 60 days. Inosine was administered intragastrically 1 time per day for 1 hour before placing rats in the chamber. After sessions of hypertension for 1, 7, 15, 30 and 60 days, animals were decapitated from the experiment under anesthesia. Immediately after decapitation, the thyroid gland was removed together with the tracheo-guttural complex, dissection of the thyroid gland. The results of the parameters of thyroid mass were processed with the help of statistical programs, the probability error was less than 5% (p <0.05). Results and discussion. The thyroid gland organometry program included measuring the length, width, and thickness of each lobe using a caliper. The received data were registered in the protocols of material intake. Determination of the volume of the thyroid gland was carried out according to the formula V = (A × B × C × p / 6) × 100, where V is the volume of the lobe of the gland, A is the length, B is the width, and C is the thickness of each lobe. We studied the dynamics of mass, length, thickness and width of rat thyroid lobes parameters as well as the volume after prolonged exposure to the organism of chronic hyperthermia in combination with the use of inosine. Conclusions. There was a slight decrease in all the thyroid organometric parameters in rats of reproductive age under the influence of moderate chronic hyperthermia combined with the use of inosine, in comparison with those in the control group.