Nuclear Factor Kappa Beta (NF-?B) and Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Expression in Spinal Cord Injury of Rats

Spinal cord injury is a life threatining condition. It is essential to evaluate spinal cord injury in the field of forensic medicine. Spinal cord injury affects the function of neurons and glia cells with inflammation and degenerative effects. Male Sprague Dawley rats (n: 20) were divided as control, trauma, Animals were applied a surgical procedure causing spinal cord injury and treated for 7 days then sacrified under anesthesia. The spinal cords were dissected and fixed in 10 % formaldehyde solution for immunohistochemical evaluations. In spinal cord injury increased cytokine activity was increased by increasing. Nuclear factor kappa beta (NF-B) expression in macrophage cells and apoptotic neurons and glial cells due to inflammation around blood vessels due to spinal cord injury. Platelet endothelial cell adhesion molecule-1 (PECAM-1) expression was positive in endothelial cells, PECAM-1 expression was significant in some hypertrophic funicular and radicular cells in substantia grisea. The most important factors in spinal cord injury is to increase the proteins that cause inflammation by disrupting the blood vessel structure and to show the activation of signaling pathways in inducing angiogenesis.