Role of Neutrophil: Lymphocyte Ratio as a Predictive Marker in the Diagnosis of Acute Coronary Syndrome

Background: Acute Coronary Syndrome (ACS) is one of the prevalent conditions, responsible for fatal heart attack and heart failure & leading cause of mortality and morbidity worldwide. Aims and Objectives: To study NLR-Neutrophil Lymphocyte Ratio as a predictive marker in diagnosis of patients with ACS. Materials and Methods: A prospective study of 66 cases admitted in Princess Esra Hospital with diagnosis of ACS were studied, their CBC reports within 72hours of onset of symptoms were collected, NLR were analysed. After informed consent, 2ml of venous blood collected from antecubital vein under aseptic precautions in a K2 EDTA vacutainer. Samples were run on Sysmex XN550 automated 5part analyser and values of WBC differential count reconfirmed on Peripheral blood Smear. Results: Gender Distribution: Frequency Percentage Male 32 48.5 Female 34 51.5 Total 66 Discussion: In our study of 66 cases, there was slight female preponderance and majority of the females were of post-menopausal age group, 48.5%-males, 51.5%-females. Majority of patients had Neutrophilic leucocytosis with an elevated NLR. Most of patients fell in age group of 46-55years. P VALUE was calculated by applying Student T test and was found to be 0.00294. P value is statistically significant if Pless than0.05. C. Chen, et al, described NLR positively correlated with Myocardial damage. In a study by A. M. Shumailah, et al, NLR was found to be the strongest predictive marker for ACS, [p value=0.014]. CONCLUSION: NLR can be used as a predictive marker for the diagnosis of ACS. The study recommends using NLR as a simple, inexpensive, and widely available inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS.