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Association/Dissociation of Caveolin-1 and Nitric Oxide Synthase in Preserving Renal Medulla Function during Hemorrhage and Aging |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.11, No. 4)Publication Date: 2021-01-05
Authors : Noelia Daniela Arreche; Gustavo Cernadas; María Bernardita Puchulu; Andrea Lorena Fellet; Ana María Balaszczuk;
Page : 332-338
Keywords : Caveolin-1; Nitric oxide; Hemorrhage; Aging; Kidney;
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Abstract
Caveolin-1 is a negative regulator of endothelial nitric oxide synthase (eNOS), as its interaction and binding suppress the activity of eNOS by making caveolin–eNOS complex. The critical role of caveolin-1 and eNOS in the renal medulla during hypovolemic state and aging is unclear.
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