DEVELOPMENT AND VALIDATION OF UV SPECTROP HOTOMETRIC ES TIMATION OF CEFADROXIL IN BULK A ND TABLET DOSAGE FOR M USING AREA UNDER CURVE METHOD

A simple, precise, accurate, and economical UV visible spectrophotometric method has b een developed for estimation of Cefadroxil drug by AUC method. The standard and sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at waveleng th range 260 - 266 nm. The linearity was established over the concentration range of 05 - 25 μg/ml for Cefadroxil with correlatio n coefficient value of 0.9993 . Precision studies showed that % relative standard deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.26 %. The proposed method has been valida ted as per ICH guidelines. Keywords : Cefadroxil, UV visible spectrophotometry, AUC, Method Validation.