Liquisolid: A Novel Technique for Dissolution Enhancement of Poorly Soluble Drugs

The poor dissolution characteristic of water insoluble drugs is a major challenge for formulation scientists. About 50% of orally administered drugs suffer from formulation difficulties related to their water insolubility. Thus it is rate limiting step for achieving optimum bioavailability of such drugs by pharmaceutical industry with developments of new pharmaceutical products.There are various methods but liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution and release properties. Liquisolid system is characterized by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in-vitro release and in-vivo evaluation.