A Review on Nanosuspensionspromising Drug Delivery Strategy

Nanotechnology has emerged as a tremendous field in the medicine.Nano refers toparticles size range of 1-1000nm. Nanosuspensions are part of nanotechnology. Many of the drug candidates are exhibiting poor aqueous solubility. Solubility of a drug can be a limiting factor for its formulation into a suitable dosage form and it influences the effectiveness of a drug to a large extent. Nanosuspensions are defined as the sub-micron colloidal dispersions of pure drug particles stabilized by surfactants. Nanosuspensions differ from nanoparticles and solid lipid nanoparticles with respect to the fact that nanoparticles are polymeric colloidal carrier of drugs while SLN (solid-lipid nanoparticle) are lipidic carrier of drugs. Nanosuspensions can be successfully utilized for the delivery of poorly water soluble drug candidates. Formulation of lipophillic drugs into nanosuspensions improves their stability and also enhances their bioavailability significantly. Nanosuspensions have unique advantages for which they have been utilized for the production of dosage forms suitable for administration through oral, parenteral, ocular and pulmonary routes. Nanosuspensions can be manufactured using the ‘Top Down’ or ‘Bottom’s up’ technology and employ a variety of components including surfactants for stability purposes and polymers for sustained release of drug in certain formulations.