INDICATORS OF CYTOKINE REGULATION IN NEWLY DIAGNOSED PULMONARY TUBERCULOSIS WITH DIFFERENT SENSITIVITY TO CHEMOTHERAPEUTIC DRUGS, DEPENDING ON THE INDICATORS OF THYROID HOMEOSTASIS AND THE LEVEL OF CORTISOL

Objective: to evaluate the performance of cytokine regulation of pulmonary tuberculosis with varying sensitivity to antiTB drugs according to thyroid function and level of cortisol. Materials and methods. Studied the levels of interleukins (IL) IL-6, IL-10, IL-18 in serum of patients with pulmonary tuberculosis (TB) using immunoenzymatic analysis. Results. There was an increase in IL-6, IL-18 and IL-10 in TB patients irrespective of the type of sensitivity to chemotherapeutic drugs. Conclusions. In patients without impaired thyroid homeostasis with high level of cortizol, irrespective of the type of sensitivity probable increase in the level of IL-6,18,10 is determined, and in patients with impaired thyroid homeostasis and high level of cortizol the level of IL-6,18,10 was significantly lower (p <0.05 ).