ASSESSMENT OF PROGNOSTIC SIGNIFICANCE OF EXPRESSION LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN COLORECTAL CANCER

Neoangiogenesis is the most significant stage of tumor progression. The most important is proangiogenic factor VEGF. Objective: To evaluate the prognostic significance of the expression level of VEGF1 in colon cancer. Materials and Methods: the clinical and morphological analysis of 72 cases of colorectal cancer resected between 2001 and 2011 was performed. Immunohistochemical studies using mouse monoclonal antibodies to VEGF1 were performed in the laboratory of Collegium Medicum in Bydgoshch. Results: low positivity of VEGF expression in colon cancer indicates low differentiation of tumors with high proliferative, invasive and metastatic potential.