COMPARATIVE STUDIES OF LORNOXICAM SOLID DISPERSIONS WITH DIFFERENT CARRIERS AND METHOD OF PREPARATIONS

The current work is focused on comparing the effect of method of preparation and the type of carrier in improving the dissolution rates of lornoxicam solid dispersions. The study was performed by preparing solid dispersions of lornoxicam with water soluble carriers like PEG 4000, PEG 6000, PVP K30, Urea and milk using methods like fusion, solvent evaporation and freeze drying. Among all, solid dispersion with PVP K30 and lornoxicam had shown up to 80% drug release at the end of 1 hour dissolution. Evaluation studies like Fourier Transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), XRay Diffraction studies (XRD) showed change in crystallinty of lornoxicam-PVP K30 solid dispersion by freeze drying. XRD studies proved partial conversion of lornoxicam into amorphous form. Solid dispersion of lornoxicam with PVP K 30 prepared by freeze drying had shown high dissolution compared to lornoxicam and their carriers. Dissolution parameters like DP30, DE60 were calculated for lornoxicam and lornoxicam-PVP K30 dispersion and higher DE60 values were observed for freeze dried preparations. Freeze drying method for preparing solid dispersion was found to be a practical and efficient method in achieving higher dissolution rates. Stability studies were conducted for a period of 3 months for the optimized dispersion and found to be stable. Key words: Lornoxicam, FTIR, X-Ray Diffraction, Freeze drying